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At baseline,the a88 patients receiving aspirin and the 184 patients receiving placebo had similar demographic,ultrasonographic,and laboratory characteristics.The median duration of follow-up was 2.3 years.The annual rate of all ischemic events and death from any cause was 12.3%for the placebo group and 11.0%for the aspirin group(P=0.61).The Cox proportional hazards analysis yielded an adjusted hazard ratio(aspirin-placebo)of 0.99 (95%CI,0.67 to 1.46;P=0.95).The annual rates for vascular events only were 11%for the placebo group and 10.7%for the aspirin group(P=0.99).The multivariate analysis yielded a hazard ratio of 1.08(CI,0.72 to 1.62;P=0. 71).Aspirin did not have a significant long-term protective effect in asymptomatic patients with high-grade(>/=50%)carotid stenosis. |
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